Strategies In Oral Drug Delivery 2008

HOW WILL YOU KEEP UP?
Permeability, solubility, metabolism, transporters, cell cultures, salt selection, pre-diction, regulatory landscape — the list goes on and on. It is impossible for one person to know it all. Yet you are still responsible for developing a drug product.

The solution is to get help. Create a network of colleagues that can provide you that expertise and work with you to over come your challenges. To do that, you’ll need an understanding of their worlds. Come to ODD09 where you’ll receive an intensive course that will enable you to start to build that network. You have the opportunity to learn from experts recognized world wide. So take the first step.

Program Goal
To provide an in-depth focus on oral drug delivery, biopharmaceutics, methods for estimating and evaluating drug absorption, and strategies for achieving optimal drug delivery and absorption from the gastrointestinal tract. The course will include problem and demonstration sessions, and attendance will be limited to 70 participants, to enhance interaction between faculty and students.

Topics Covered

• GI Physiological Variables and Drug Absorption
• Dissolution and Oral Absorption Evaluation
• Intestinal and Hepatic Transport and Metabolism
• Oral Delivery Systems: Formulation and Regulatory Standards
• Biopharmaceutics: From Discovery to Regulation
• Daily Panel Discussions (Free demo software also included)

Educational Objectives
Following this course, participants will be able to:

• Understand the gastrointestinal, drug and dosage form processes controlling absorption.
• Understand the relevance and utility of in vitro tissue culture models to in vivo absorption.
• Understand and apply methods for estimating and evaluating oral drug absorption, including high throughput screening (HTS) methods and computer simulation and prediction methods.
• Evaluate and develop appropriate methods to optimize oral delivery.
• Be able to identify the potential rate limits to oral drug absorption.
• Understand intestinal and hepatic metabolic pathways and their impact on absorption and systemic availability.
• Identify appropriate types of controlled release dosage forms for specific drugs.
• Identify GI physiological variables influencing absorption rate and extent.
• List metabolism and transporter factors e.g., P-gp, influencing absorption and systemic availability.
• Have an understanding of molecular membrane transporters and their importance for drug absorption and excretion.
• Analyze and simulate pharmacokinetic absorption rate and plasma level.
• Understand the current FDA bioavailability (BA) and bioequivalence (BE) standards and how they may evolve in the future.

Faculty List
Amidon, Bermejo, Cook, Gupta, Hilfinger, Langguth, Lennernas, KD Lee, Polli, Tamai, Woltosz, Yamashita, Yu

Exhibitor Space Available
Contact Carrie Sini at 734 663-4233, ext. 243 for information on availability and pricing.

For more information on ODD08, contact Carrie Sini at 734 663-4233, ext. 243 or email: csini@ddfint.org.