ODD10 – Schedule

March 7-12, 2010 • Lake Tahoe, Nevada

 

Day	Lecture	Title	Speaker
Sunday	3/7	Opening Day
6:00 - 7:00		Registration
7:00 - 9:00		Reception
Monday	3/8	GI Physiological Variables and Drug Absorption
7:30 - 8:30		Breakfast
8:30 - 9:20	1	Oral Drug Delivery: A Mechanistic Approach	Amidon
9:20 - 10:30	2	Gastrointestinal Physiological Variables	Bermejo
10:30 - 10:50		Break
10:50 - 12:00	3	GI Permeability and Transit: Oral Absorption	Amidon
12:00 - 1:30		Lunch
1:30 - 2:20	4	Mechanisms of Intestinal Membrane Permeation	Lennernäs
2:20 - 3:10	5	Cellular/Molecular Mechanisms of Transport across Epithelium	Lee
3:10 - 3:30		Break
3:30 - 4:20	6	Cell Culture Methods and Permeability	Polli
4:30 - 6:00	7	Poster Session and Exhibits/Wine and Cheese
Tuesday	3/9	Methods for Evaluation of Oral Drug Absorption and Drug Formulation
7:00 - 8:00		Breakfast
8:00 - 8:50	8	Overview - Permeability Methods from In Vitro to In Vivo human	Lennernäs
8:50 - 9:40	9	Biophysical Predictive Absorption Models and Applications	Bermejo
9:40 - 10:30	10	In Vitro and In Vivo Approaches to Drug Absorption Screening	Yamashita
10:30 - 10:45		Break
10:45 - 11:35	11	Analysis of Drug Absorption from PK Studies	Langguth
11:35 - 12:25	12	In Vivo Dissolution and IVIVC	Cook
12:30 - 2:00		Lunch
2:00 - 2:50	13	Unit Operations	Gupta
2:50 - 3:40	14	Dissolution Methodologies and Issues	Abrahamsson
3:40 - 4:00		Break
4:00 - 4:45	15	3 Case Study Presentations
4:45 - 5:30	16	Unit Operations	Gupta
6:00 - 10:00		Dinner and Social Event
Wednesday	3/10	Intestinal and Hepatic Transport and Metabolism
7:30 - 8:30		Breakfast
8:30 - 9:20	17	Role of Transporters in Drug Absorption	Tamai
9:20 - 10:10	18	Liver Transport & Metabolism	Lennernäs
10:10 - 11:00	19	Intestinal Metabolism: Mechanisms and Effect on Fsys	Langguth
11:00		Lunch (Box Lunch)
		Wednesday Afternoon Free
7:00 - 10:00		Hands On - In Silico Predictions of Drug Absorption and Bioavailability Computer Demonstrations - software provided - please bring laptops
Thursday	3/11	Poorly Soluble Drugs
7:30 - 8:30		Breakfast
8:30 - 9:20	20	Selected Formulation Approaches for Water Insoluble Drugs	Langguth
9:20 - 10:15	21	Dissolution of Insoluble Drugs: Ex Vivo Fluid Studies	Abrahamsson
10:15 - 10:30		Break
10:30 - 11:20	22	Regulatory Evaluation of Pharmaceutical Quality	Yu
11:20 - 12:10	23	Development of BCS Class 2 to 4 Compounds: Recommendations and Experiences from a Company Consortium	Yamashita
12:10 - 1:30		Lunch
1:30 - 2:20	24	Dissolution Absorption and IVIVC	Polli
2:20 - 3:10	25	3 Case Studies and Discussion
3:10 - 3:25		Break
		Oral Delivery Challenges
3:25 - 4:05	26	Prodrug Approaches to Enhancing Absorption	Tamai
4:05 - 4:45	27	Enhancement of Oral Absorption of Polar Drugs	Hilfinger
4:45 - 5:30	28	Mucosal Immune Systems and Vaccine Delivery	Lee
Friday	3/12	Biopharmaceutics: From Discovery to Regulation
7:30 - 8:30		Breakfast
8:30 - 9:40	29	The Science of BE Requirements: Perspective from a Pharmaceutical Company	Cook
9:40 - 10:30	30	Evolving Bioequivalence Standard	Yu
10:30-11:00	31	Biopharmaceutics & BCS: Future Role in Discovery, Development and Regulation	Amidon