ODD12: Predicting Drug Absorption

February 26 - March 2, 2012 • Lake Tahoe, Nevada - Harrah's

 

How will you keep up?

Permeability, solubility, metabolism, transporters, cell cultures, salt selection, pre-diction, regulatory landscape — the list goes on and on. It is impossible for one person to know it all. Yet you are still responsible for developing a drug product.

 

The solution is to make friends. Create a network of colleagues that can provide you that expertise and work with you to overcome your challenges. To do that, you’ll need an understanding of their worlds. Come to ODD12 where you'll receive an intensive course that will enable you to start to build that network. You have the opportunity to learn from experts recognized worldwide. So take the first step.

 

Organizers

Gordon L. Amidon (Ann Arbor, Michigan, USA)
James Polli (Baltimore, MD, USA)
Peter Langguth (Mainz, Germany)
Hans Lennernäs (Uppsala, Sweden)

 

Location

Harrah's Lake Tahoe

15 Highway 50

Stateline, NV  89449
1-800-786-8208

http://www.harrahslaketahoe.com

 

Schedule

Click here to see the schedule of events

 

Registration & Payment Options (pre-registration is required)

• Register and pay by credit card - https://odd.ddfint.org/
• Register and pay by check - https://odd.ddfint.org/registration-check

Program Goal

To provide an in-depth focus on oral drug delivery, biopharmaceutics, methods for estimating and evaluating drug absorption, and strategies for achieving optimal drug delivery and absorption from the gastrointestinal tract. The course will include problem and demonstration sessions, and attendance will be limited to 40 participants, to enhance interaction between faculty and students.

 

New Features

• Hands-On Computational Sessions
• Software and Computers Provided
• OpenOffice™, GastroPlus™, ADMET Predictor™, MedChem Designer™
• Predicting Absorption
• Provisional BCS Classification
• Classical Bioequivalence Determination
• Absorption Analysis
• Poster and Exhibit Session with Discussion

Educational Objectives

Following this course, participants will be able to:

• Understand the gastrointestinal, drug and dosage form processes controlling absorption.
• Understand the relevance and utility of in vitro tissue culture models to in vivo absorption.
• Understand and apply methods for estimating and evaluating oral drug absorption, including high throughput screening (HTS) methods and computer simulation and prediction methods.
• Evaluate and develop appropriate methods to optimize oral delivery.
• Be able to identify the potential rate limits to oral drug absorption.
• Understand intestinal and hepatic metabolic pathways and their impact on absorption and systemic availability.
• Identify appropriate types of controlled release dosage forms for specific drugs.
• Identify GI physiological variables influencing absorption rate and extent.
• List metabolism and transporter factors e.g., P-gp, influencing absorption and systemic availability.
• Have an understanding of molecular membrane transporters and their importance for drug absorption and excretion.
• Analyze and simulate pharmacokinetic absorption rate and plasma level.
• Understand the current FDA bioavailability (BA) and bioequivalence (BE) standards and how they may evolve in the future.

Faculty List

Amidon, Bermejo, Bolger, Cook, Langguth, Lennernäs, Lionberger, Polli, Tamai

 

For more information on ODD12, contact Gail Benninghoff at (734) 764-2226.