Drug Delivery Foundation

ODD12 – Schedule

February 26-March 2, 2012 • Lake Tahoe, Nevada

 

Day

Lecture

Title

Speaker

Sunday

2/26

Opening Day

7:00 - 9:00   Welcome Reception (Harrah's)

 

Monday

2/27

Predicting Absorption and BCS
Morning   Predicting Oral Drug Absorption: Soluble Drugs  
8:30-9:30   Human Absorption Prediction: The Global View Amidon
9:30-10:30   Gastrointestinal Physiological Variables Bermejo
10:30-10:45   Coffee  
10:45-11:45   Mechanisms of Intestinal Membrane Permeation Lennernäs
Afternoon   "Hands-On" Computations: Predicting Absorption and Provisional BCS Classification  
1:30-2:30   Partition Coefficient in silico and Absorption Estimation - (OpenOffice.org™ Calc (MS Excel compatible) Amidon
2:30-3:30   BCS Classification in silico using log P as a surrogate for Peff
- (OpenOffice.org™ Calc  (MS Excel compatible)		 Amidon / Bolger
3:30-3:45   Break: Coffee  
3:45-5:00   Intro to MedChem Designer™ and S+LogP, Provisional BCS Amidon / Bolger

Tuesday

2/28

Permeability
Morning   Experimental Methods to Measure Permeability  
8:30-9:30   Human Jejunal Permeability: The Gold Standard Lennernäs
9:30-10:30   Permeability Methods in situ: Rat/Mouse/Dog Bolger / Amidon
10:30-10:45   Coffee  
10:45-11:45   Cell Culture Permeability Methods in vitro Polli
11:45-12:30   Estimating Solubility Amidon
Afternoon   "Hands-On" Computations using Integrated Software  
1:30-2:30   The Absorption Spreadsheet (OpenOffice.org):
Estimating: MlogP, MH-Solubility, Simple Peff, Aqueous Diffusivity		 Bolger
2:30-3:30   mating Biorelevant Solubility from Aqueous Solubility & logP Bolger
3:30-3:45   Coffee  
3:45-5:30   ADMET™ Predictor: Modeling & Applicability Domain
Comparison of Estimation methods and Applicability Domain
Woltosz
Evening   Reception, Dinner and Entertainment (7:00-10:00) DDF

Wednesday

2/29

Dissolution and Absorption Methodologies
Morning   Dissolution and IVIVC  
8:30-9:30   Dissolution Methodology and Current Challenges Polli
9:30-10:30   Analysis of Drug Absorption: PK Analysis and IVIVC Langguth
10:30-10:45   Coffee  
10:45-11:45   Oral Absorption and Bioequivalence Bermejo
11:45-12:30   "Hands-On" Hands-on Computations: Bioequivalence Bermejo / Cook
12:30-2:00   Lunch  
Afternoon   Posters and Exhibits available for viewing  
Evening   Poster Session and Exhibits  
7:00-8:00   "If we Designed Airplanes like we Designed Drugs…" Woltosz
8:00-10:00   Posters; Wine and Cheese Amidon

Thursday

3/1

Oral Delivery Based BCS Class: Langguth, Polli

Morning   Oral Delivery:  Class I (CR), BCS Class II (Solubilization), Class III (Prodrugs) and IV  
8:30-9:30   BCS Class I: IR and CR Langguth
9:30-10:30   BCS Class II: Solubilization Methods Langguth
10:30-10:45   Coffee  
10:45-11:45   BCS Class III: Prodrugs and Transporters Tamai
12:00-1:30   Lunch  
Afternoon   "Hands-On" Computations Integrated Software  
1:30-2:30   "Hands-On" Computations: Wagner-Nelson, IVIVC Amidon / Langguth
2:30-3:30   Analysis of Examples Data

Cook / Polli / Bermejo
3:30-3:45   Coffee  
3:45-5:30   Mechanistic ACAT Deconvolution and IVIVCs for Highly Variable and MR Formulations. Bolger

Friday

3/2

Oral Delivery: The Future
Morning   Future Regulation and Molecular Transport  
8:30-9:30   BCS Based Regulatory Standards: Evolving World Wide Cook
9:30-10:30   Regulatory Future: Pharmaceutical Quality Lionberger
10:30-11:30   Modern Molecular Membrane Transport: Molecular ADME Tamai
11:30-11:45   Closing Remarks Amidon